Selected Recent Publications


See full list of cited publications here.

Franchetti MK, Bharadwaj PK, Nguyen LA, Van Etten EJ, Klimentidis YC, Hishaw GA,

Trouard TP, Raichlen DA, Alexander GE. Interaction of age and self-reported physical

sport activity on white matter hyperintensity volume in healthy older adults. Frontiers

in Aging Neuroscience, in press.

Glisky EL, Alexander GE, Hou M, Kawa K, Woolverton CB, Zigman EK, Nguyen LA, Haws

K, Figueredo AJ, Ryan L. Differences between young and older adults in unity and

diversity of executive functions. Aging, Neuropsychology, and Cognition, in press.

Hardcastle C, O'Shea A, Kraft J, Albizu A, Evangelista ND, Hausman HK, Boutzoukas EM, 

Van Etten EJ, Bharadwaj PK, Song H, Smith SG, Porges E, Dekosky S, Hishaw GA, Wu SS,

Marsiske M, Cohen R, Alexander GE, Woods AJ. Contributions of hippocampal volume

to cognition in healthy older adults. Frontiers in Aging Neuroscience, in press.

Alexander GE, Lin L, Yoshimaru ES, Bharadwaj PK, Bergfield KL, Hoang LT, Chawla MK,

Chen K, Moeller JR, Barnes CA, Trouard TP. (2020) Age-Related Regional Network

Covariance of Magnetic Resonance Imaging Gray Matter in the Rat. Frontiers In Aging

Neuroscience, 12, 267.


Sayre MK, Pontzer H, Alexander GE, Wood BM, Pike IL, Mabulla AZP, Raichlen DA. Aging

and physical function in East African foragers and pastoralists. Philosophical

Transactions of the Royal Society B, in press.


Kraft JN, O'Shea A, Albizu A, Evangelista ND, Hausman HK, Boutzoukas E, Nissim NR,

Van Etten EJ, Bharadwaj PK, Song H, Smith SG, Porges E, Wu S, Marsiske M, Cohen R,

Alexander GE, Woods AJ. Structural neural correlates of double decision performance

in  older adults. Frontiers in Aging Neuroscience, in press.

Van Etten EJ, Bharadwaj PK, Nguyen LA, Hishaw GA, Trouard TP, Alexander GE. Right

hippocampus volume mediation of subjective memory complaints by hypertension

status in healthy aging. Neurobiology of Aging, in press.


Hausman HK, O'Shea A, Kraft JN, Boutzoukas EM, Evangelista ND, Van Etten EJ,

Bharadwaj PK, Smith SG, Porges E, Hishaw GA, Wu S, DeKosky S, Alexander GE,

Marsiske M, Cohen R, Woods AJ. (2020) The role of resting-state network functional

connectivity in cognitive aging. Frontiers in Aging Neuroscience, 12, 171, 1-10.

Raichlen DA, Bharadwaj PK, Nguyen LA, Franchetti MK, Solorio AR, Alexander GE. (2020) Effects of simultaneous cognitive and aerobic exercise training on duel-task walking performance in healthy older adults: results from a pilot randomized controlled trial. BMC Geriatrics, 20, 83.

Raichlen DA and Alexander GE. (2020) Why your brain needs exercise: Key transitions in the evolutionary history of humans may have linked body and mind in ways that we can exploit to slow brain aging. Scientific American, Vol 322, Issue 1, 27-31.

​Raichlen DA, Klimentidis YC, Bharadwaj PK, Alexander GE. (2019) Differential associations of engagement in physical activity and estimated cardiorespiratory fitness with brain volume in middle-aged to older adults. Brain Imaging and Behavior,


Raichlen DA, Klimentidis YC, Hsu C-H, Alexander GE. (2019) Fractal complexity of daily physical activity patterns differs with age over the lifespan and is associated with mortality in older adults. Journal of Gerontology, Series A: Biological Sciences and

Medical Sciences, 74, 1461-1467.

Klimentidis YC, Raichlen DA, Bea J, Garcia DO, Wineinger N, Mandarino LJ, Alexander GE, Chen Z, Going SB. (2018) Genome-wide association study of habitual physical activity in over 377,000 UK Biobank participants identifies multiple variants including CADM2 and APOE. International Journal of Obesity, 42, 1161-1176.

Stonnington CM, Chen Y, Savage CR, Lee W, Bauer RJ, Sharieff S, Thiyyagura P, Alexander GE, Caselli RJ, Locke DEC, Reiman EM, Chen K. Predicting imminent progression to clinical stages of Alzheimer’s disease using volumetric MRI and FDG-PET. Journal of Alzheimer's Disease, 63, 603-615.

Woods AJ, Cohen R, Marsiske M, Alexander GE, Czaja SJ, Wu S. (2018) Augmenting cognitive training in older adults (The ACT Study): Design and methods. Contemporary Clinical Trials, 65, 19-32.

Cohen RA and Alexander GE. (2017) Using the Telephone Interview for Cognitive Status and Telephone Montreal Cognitive Assessment for evaluating vascular cognitive impairment: Promising call or put on hold? Stroke, 48, 2919-2921.


Raichlen DA and Alexander GE. (2017) Adaptive Capacity: An evolutionary-neuroscience model linking exercise, cognition, and brain health. Trends in Neurosciences, 40, 7.

Kern C, Wright CB, Bergfield KL, Fitzhugh M, Chen K, Moeller JR, Nabizadeh N, Elkind MS,

Sacco RL, Stern Y, DeCarli CS, Alexander GE. (2017) Blood pressure control in aging predicts cerebral atrophy related to small-vessel white matter lesions. Frontiers in Aging Neuroscience, 9, 132.

Alexander GE. (2017) An emerging role for imaging white matter in the preclinical risk for Alzheimer’s disease: Linking B-amyloid to myelin . JAMA Neurology, 74, 17-19.

Raichlen DA, Bharadwaj PK, Fitzhugh MC, Haws KA, Torre GA, Trouard TP, Alexander GE. (2016) Differences in resting state functional connectivity between young adult endurance athletes and healthy controls. Frontiers in Human Neuroscience, 10, 610.

Nguyen LA, Haws KA, Fitzhugh MC, Torre GA, Hishaw GA, Alexander GE. (2015) Interactive effects of subjective memory complaints and hypertension on learning and memory performance in the elderly. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn., Neuropsychol Dev Cogn B Aging Neuropsychol Cogn, 23, 154-70.


Raichlen D and Alexander GE. (2014) Exercise, APOE genotype, and the evolution of the human lifespan. Trends in Neurosciences, 37, 247-55. (Featured Article on Journal Cover)


Burns CM, Chen K, Kaszniak AW, Lee W, Alexander GE, Bandy D, Fleisher A, Caselli RJ, Reiman ER (2013) Higher serum glucose levels are associated with cerebral hypometabolism in Alzheimer's regions. Neurology, 80, 1557-64.


Reiman EM, Quiroz YT, Fleisher AS, Chen K, Velez-Pardo C, Jimenez-Del-Rio M, Fagan AM, Shah AR, Alvarez S, Arbelaez A, Giraldo M, Acosta-Baena N, Sperling RA, Dickerson B, Stern  CE, Tirado V, Munoz C, Reiman RA, Huentelman MJ, Alexander GE, Langbaum JBS, Kosik KS, Tariot PN, Lopera F. (2012) Brain abnormalities in young adults at genetic risk for autosomal dominant  Alzheimer’s disease. The Lancet Neurology, 11, 1048-56.

Alexander GE, Ryan L, Bowers D, Foster TC, Bizon JL, Geldmacher DS, Glisky EL. (2012) Characterizing cognitive aging in humans with links to animal models. Front Aging Neurosci. 2012;4:21. doi: 10.3389/fnagi.2012.00021. (PubMed: 22988439)

Alexander GE, Bergfield KL, Chen K, Reiman EM, Hanson KD, Lin L, Bandy D, Caselli RJ, Moeller JR. (2012) Gray matter network associated with risk for Alzheimer's disease in young to middle-aged adults.Neurobiol Aging. 2012 Dec;33(12):2723-32. doi: 10.1016/j.neurobiolaging.2012.01.014. Epub 2012 Mar 8.
(PubMed: 22405043)


Bergfield KL, Hanson KD, Chen K, Teipel SJ, Hampel H, Rapoport SI, Moeller JR, Alexander GE. (2010) Age-related networks of regional covariance in MRI gray matter: Reproducible multivariate patterns in healthy aging. NeuroImage, 49(2):1750-9.

(PubMed: 19796692)

Smith JF, Alexander GE, Chen K, Husain FT, Kim J, Pajor N, Horwitz B. (2010) Imaging systems level consolidation of novel associate memories: A longitudinal neuroimaging study. NeuroImage, 50(2):826-36.

(PubMed: 19948227)


Caselli RJ, Dueck AC, Osborne D, Sabbagh MN, Connor DJ, Ahern GL, Baxter LC, Rapcsak SZ, Shi J, Woodruff BK, Locke DE, Snyder CH, Alexander GE, Rademakers R, Reiman EM. (2009) Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect. New England Journal of Medicine 361(3):255-63

(PubMed: 19605830)

Chen K, Reiman EM, Zhongdan H, Caselli RJ, Bandy D, Alexander GE. (2009) Linking functional and structural brain images with multivariate network analyses: A novel application of the partial least square method. NeuroImage 47(2):602-10

(PubMed: 19393744)


Hua X, Lee S, Yanovsky I, Leow AD, Chou YY, Ho AJ, Gutman B, Toga AW, Jack CR Jr, Bernstein MA, Reiman EM, Harvey DJ, Kornak J, Schuff N, Alexander GE, Weiner MW, Thompson PM; Alzheimer's Disease Neuroimaging Initiative. (2009) Optimizing power to track brain degeneration in Alzheimer's disease and mild cognitive impairment with tensor-based morphometry: An ADNI study of 515 subjects. NeuroImage 48(4):668-81

(PubMed: 19615450)

Alexander GE, Chen K, Aschenbrenner M, Merkley TL, Santerre-Lemmon LE, Shamy JL, Skaggs WE, Buonocore MH, Rapp PR, Barnes CA (2008) Age-related regional network of magnetic resonance imaging gray matter in the rhesus macaque. Journal of Neuroscience 28(11):2710-8

(PubMed: 18337400)


Ryan, L, Alexander GE (2007) Neuroimaging: Overview of Methods and Applications. In: Luecken LJ, Gallo LC (eds.) Handbook of Physiological Research Methods in Health Psychology. SAGE Publications.


Alexander GE, Chen K, Merkley TL, Reiman EM, Caselli RJ, Aschenbrenner M, Santerre-Lemmon L, Lewis DJ, Pietrini P, Teipel SJ, Hampel H, Rapoport SI, Moeller JR (2006) Regional network of magnetic resonance imaging gray matter volume in healthy aging. NeuroReport 17(10):951-6

(PubMed: 16791083)

Smith JF, Chen K, Johnson S, Morrone-Strupinsky J, Reiman EM, Nelson A, Moeller JR, Alexander GE (2006) Network analysis of single-subject fMRI during a finger opposition task. NeuroImage 32(1):325-32

(PubMed: 16733091)


Reiman EM, Chen K, Alexander GE, Caselli RJ, Bandy D, Osborne D, Saunders AM, Hardy J (2005) Correlations between apolipoprotein E epsilon4 gene dose and brain-imaging measurements of regional hypometabolism. Proceedings of the National Academy of Sciences of the USA 102(23):8299-302

(PubMed: 15932949)

Chen K, Reiman EM, Alexander GE, Bandy D, Renaut R, Crum WR, Fox NC, Rossor MN (2004) An automated algorithm for the computation of brain volume change from sequential MRIs using an iterative principal component analysis and its evaluation for the assessment of whole-brain atrophy rates in patients with probable Alzheimer’s disease. NeuroImage 22(1):134-43

(PubMed: 15110003)


Alexander GE, Reiman EM (2003) Neuroimaging. In: Weiner MF, Lipton AM (eds.) The Dementias: Diagnosis, Treatment, and Research, 3rd edition. Washington, D.C.: American Psychiatric Press, Inc.


Alexander GE, Chen K, Pietrini P, Rapoport SI, Reiman EM (2002) Longitudinal PET Evaluation of Cerebral Metabolic Decline in Dementia: A Potential Outcome Measure in Alzheimer’s Disease Treatment Studies. American Journal of Psychiatry 159(5):738-45

(PubMed: 11986126)

Alexander GE (2002) Alzheimer’s Disease. In: McGraw-Hill Encyclopedia of Science and Technology, 9th edition. New York, NY: McGraw-Hill.

  • Facebook Classic
  • Twitter Classic
  • Google Classic
  • RSS Classic
This site was designed with the
website builder. Create your website today.
Start Now